DOSE-RESPONSE RELATION FOR ATRACURIUM, ORG NC45 AND PANCURONIUM
نویسندگان
چکیده
منابع مشابه
Dose-response relation for atracurium, ORG NC 45 and pancuronium.
The potencies of atracurium, Org NC 45 and pancuronium were determined using cumulative dose-response curves. The effective doses producing 95% twitch depression were 279 microgram kg-1, 56 microgram kg-1 and 64 microgram kg-1 respectively, the relative potency being 1:5.0:4.3. The calculated log-probit dose-response curves showed the steepest slope for pancuronium, although the slopes did not ...
متن کاملAtracurium, vecuronium and pancuronium in end-stage renal failure. Dose-response properties and interactions with azathioprine.
Dose-response relations for atracurium, vecuronium and pancuronium were determined in patients in end-stage renal failure for the initial neuromuscular blockade (using three cumulative doses) and for the maintenance of stable 90% response (during continuous infusion). All measurements were during renal transplant surgery, and the interaction of azathioprine on neuromuscular blockade was estimat...
متن کاملRecovery of neuromuscular function after atracurium and pancuronium maintenance of pancuronium block.
The study was undertaken to determine whether a neuromuscular blockade induced with pancuronium but maintained with atracurium was associated with a shorter time to complete recovery after administration of neostigmine than if the blockade was maintained with pancuronium alone. Anaesthesia consisted of thiopentone, N2O/O2/enflurane and fentanyl, and the neuromuscular blockade, induced by pancur...
متن کامل[Effect of atracurium on pancuronium-induced neuromuscular block recovery.].
BACKGROUND AND OBJECTIVES Additional neuromuscular blocker doses are in general needed during wall closing after abdominal surgeries. This study aimed at determining during partial pancuronium-induced neuromuscular block recovery, the effect of additional atracurium dose on spontaneous neuromuscular block recovery. METHODS Participated in this study 30 patients divided in two groups: pancuron...
متن کاملClinical studies on Org NC 45: comparison with pancuronium.
Some actions of Org NC 45 have been compared with those of pancuronium in a study on 50 patients anesthetized with nitrous oxide and narcotic supplements. The train-of-four technique was used to assess the recovery of neuromuscular blockade and its antagonism. Org NC 45 was shown to have a duration of action from injection of the intubating dose (0.1 mg kg-1) to the reappearance of the first tw...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1982
ISSN: 0007-0912
DOI: 10.1093/bja/54.6.647